Genomic and phenotypic diversity of Listeria monocytogenes clonal complexes associated with human listeriosis.
Teresa M BergholzManoj K ShahLaurel S BurallMira Rakic-MartinezAtin R DattaPublished in: Applied microbiology and biotechnology (2018)
Listeria monocytogenes is a pathogen of significant concern in many ready to eat foods due to its ability to survive and multiply even under significant environmental stresses. Listeriosis in humans is a concern, especially to high-risk populations such as those who are immunocompromised or pregnant, due to the high rates of morbidity and mortality. Whole genome sequencing has become a routine part of assessing L. monocytogenes isolated from patients, and the frequency of different genetic subtypes associated with listeriosis is now being reported. The recent abundance of genome sequences for L. monocytogenes has provided a wealth of information regarding the variation in core and accessory genomic elements. Newly described accessory genomic regions have been linked to greater virulence capabilities as well as greater resistance to environmental stressors such as sanitizers commonly used in food processing facilities. This review will provide a summary of our current understanding of stress response and virulence phenotypes of L. monocytogenes, within the context of the genetic diversity of the pathogen.
Keyphrases
- listeria monocytogenes
- genetic diversity
- copy number
- escherichia coli
- end stage renal disease
- pseudomonas aeruginosa
- staphylococcus aureus
- human health
- biofilm formation
- candida albicans
- newly diagnosed
- ejection fraction
- chronic kidney disease
- antimicrobial resistance
- endothelial cells
- genome wide
- prognostic factors
- peritoneal dialysis
- risk assessment
- clinical practice
- intensive care unit
- social media