Photothermal and Photocatalytic Glycol Chitosan and Polydopamine-Grafted Oxygen Vacancy Bismuth Oxyiodide (BiO 1-x I) Nanoparticles for the Diagnosis and Targeted Therapy of Diabetic Wounds.
Jianglong KongSihan MaRunxuan ChuJiawen LiuHongrui YuMeiru MaoXiaohan GeYuting SunYi WangPublished in: Advanced materials (Deerfield Beach, Fla.) (2023)
Treatment of diabetic wounds is a significant clinical challenge due to the massive infections caused by bacteria. In this study, multifunctional glycol chitosan and polydopamine-coated BiO 1-x I (GPBO) nanoparticles (NPs) with near-infrared (NIR) photothermal and photocatalytic abilities are prepared. When infection occurs, the local microenvironment becomes acidic, and the pH-switchable GPBO can target the bacteria of the wound site. The NIR-assisted GPBO treatment exhibits anti-bacterial effects with fast response, high efficiency, and long duration to Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. GPBO achieves excellent photothermal imaging and CT imaging of the mouse subcutaneous abscess model. With the assistance of NIR irradiation, the GPBO promotes the healing of the diabetic wound model with the effects of anti-bacteria, anti-inflammation, the M2 polarization promotion of macrophages, and angiogenesis. This is the first-time report of nano-sized BiO 1-x I. The synthesis and selected application for the imaging and targeted therapy of diabetic wounds are presented. This study offers an example of the NP-assisted precise diagnosis and therapy of bacterial infection diseases.
Keyphrases
- wound healing
- photodynamic therapy
- drug delivery
- drug release
- high resolution
- fluorescence imaging
- cancer therapy
- escherichia coli
- pseudomonas aeruginosa
- staphylococcus aureus
- type diabetes
- high efficiency
- oxidative stress
- biofilm formation
- fluorescent probe
- stem cells
- magnetic resonance imaging
- endothelial cells
- visible light
- replacement therapy
- mass spectrometry
- mesenchymal stem cells
- pet ct
- rare case