Marine-Derived Compounds and Prospects for Their Antifungal Application.
Joana CardosoDarlan Gonçalves NakayamaMaria Emília SousaEugénia PintoPublished in: Molecules (Basel, Switzerland) (2020)
The introduction of antifungals in clinical practice has an enormous impact on the provision of medical care, increasing the expectancy and quality of life mainly of immunocompromised patients. However, the emergence of pathogenic fungi that are resistant and multi-resistant to the existing antifungal therapy has culminated in fungal infections that are almost impossible to treat. Therefore, there is an urgent need to discover new strategies. The marine environment has proven to be a promising rich resource for the discovery and development of new antifungal compounds. Thus, this review summarizes more than one hundred marine natural products, or their derivatives, which are categorized according to their sources-sponges, bacteria, fungi, and sea cucumbers-as potential candidates as antifungal agents. In addition, this review focus on recent developments using marine antifungal compounds as new and effective approaches for the treatment of infections caused by resistant and multi-resistant pathogenic fungi and/or biofilm formation; other perspectives on antifungal marine products highlight new mechanisms of action, the combination of antifungal and non-antifungal agents, and the use of nanoparticles and anti-virulence therapy.
Keyphrases
- candida albicans
- biofilm formation
- staphylococcus aureus
- pseudomonas aeruginosa
- escherichia coli
- clinical practice
- end stage renal disease
- newly diagnosed
- small molecule
- ejection fraction
- prognostic factors
- palliative care
- high throughput
- stem cells
- peritoneal dialysis
- chronic kidney disease
- replacement therapy
- patient reported
- patient reported outcomes