Respiratory Failure due to Severe Obesity and Kyphoscoliosis in a 24-Year-Old Male with Molecularly Confirmed Prader-Willi Syndrome in Tertiary Hospital in Northern Tanzania.
Elichilia R ShaoLucas F KiyegiAmos O MwasamwajaKajiru KilonzoBen C J HamelPublished in: Case reports in genetics (2017)
Obesity, mild intellectual disability, hypotonia, poor sucking, cryptorchidism in males, hypogonadism, and kyphoscoliosis are common features of Prader-Willi syndrome (PWS). We report a case who had severe respiratory complications due to extreme obesity and kyphoscoliosis, which are important causes of morbidity and mortality, and discuss management. Furthermore, this is the first molecularly confirmed PWS case in Sub-Saharan Africa outside South Africa.
Keyphrases
- intellectual disability
- insulin resistance
- metabolic syndrome
- growth hormone
- weight loss
- respiratory failure
- high fat diet induced
- type diabetes
- south africa
- weight gain
- autism spectrum disorder
- early onset
- case report
- extracorporeal membrane oxygenation
- climate change
- adipose tissue
- intensive care unit
- hiv positive
- skeletal muscle
- body mass index
- physical activity
- acute respiratory distress syndrome
- respiratory tract
- replacement therapy