Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers.
Suwellen S D de AzevedoDiogo Gama CaetanoFernanda H CôrtesSylvia L M TeixeiraKarina Dos Santos SilvaBrenda HoaglandBeatriz GrinsztejnValdilea G VelosoMariza G MorgadoGonzalo BelloPublished in: Retrovirology (2017)
There is no simple relationship between systemic viral suppression and intra-host proviral diversity or rate of reservoir's reseeding in chronically infected HIV controllers. Our results demonstrate that very divergent patterns of intra-host viral diversity and divergence could be detected in the setting of natural suppression of HIV-1 replication and that ongoing evolution and reseeding of the PBMC proviral reservoir occurs in some elite controllers.