Potential involvement of oncostatin M in the immunosuppressive tumor-immune microenvironment in hepatocellular carcinoma with vessels encapsulating tumor clusters.

Yasuyuki ShigematsuKazuhito TanakaGulanbar AmoriHiroaki KandaYu TakahashiYutaka TakazawaKengo TakeuchiKentaro Inamura

Published in: Hepatology research : the official journal of the Japan Society of Hepatology (2023)

We revealed the unique pathological features of VETC-positive HCC, such as low hepatocyte differentiation, decreased OSM-positive cells, and OSM-independent vascular invasion. These findings highlight the potential interaction between VETC-positive HCC cells and their TIM through the reduction of OSM-expressing cells. This article is protected by copyright. All rights reserved.

Keyphrases

induced apoptosis
cell cycle arrest
stem cells
endoplasmic reticulum stress
cell death
signaling pathway
single cell
pi k akt
cell proliferation