Bioinformatics-based discovery of intervertebral disc degeneration biomarkers and immune-inflammatory infiltrates.
Chao SongDaqian ZhouKang ChengFei LiuWeiye CaiYongliang MeiJingwen ChenChenyi HuangZongchao LiuPublished in: JOR spine (2023)
In conclusion, the cellular senescence signaling pathway, the apoptosis signaling pathway, and associated hub genes play significant roles in the development and progression of IVDD, this finding may help direct future research on the senescence signaling route in IVDD.
Keyphrases
- signaling pathway
- pi k akt
- oxidative stress
- dna damage
- cell cycle arrest
- endothelial cells
- induced apoptosis
- epithelial mesenchymal transition
- bioinformatics analysis
- small molecule
- endoplasmic reticulum stress
- stress induced
- high throughput
- current status
- cell proliferation
- network analysis
- dna methylation
- genome wide identification
- transcription factor