Increased ROS production and DNA damage in monocytes are biomarkers of aging and atherosclerosis.

Thais A JacintoGiselle S MeirelesAnanda T DiasRafaela AiresMarcella L PortoAgata L GavaElisardo C VasquezThiago Melo C PereiraBianca Prandi CampagnaroSilvana S Meyrelles

Published in: Biological research (2018)

In this study, we demonstrate that a pro-inflammatory systemic status is associated with an impairment of functionality of monocytes during aging and that these parameters are fundamental extra-arterial contributors to the aggravation of atherosclerosis. The present data open new avenues for the development of future strategies with the purpose of treating atherosclerosis.

Keyphrases

dna damage
cardiovascular disease
dendritic cells
oxidative stress
peripheral blood
dna repair
cell death
minimally invasive
electronic health record
big data
machine learning
immune response
deep learning
artificial intelligence