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Calciprotein Particles Induce Endothelial Dysfunction by Impairing Endothelial Nitric Oxide Metabolism.

Lian FeenstraAnton G KutikhinDaria K ShishkovaHendrik BuikemaLara W ZeperArno R BourgonjeGuido KrenningJan-Luuk Hillebrands
Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)
CPPs cause endothelial cell dysfunction by impairing nitric oxide metabolism and generating oxidative stress. Our findings provide new evidence for direct effects of CPPs on ECs and pathways involved.
Keyphrases
  • nitric oxide
  • oxidative stress
  • endothelial cells
  • nitric oxide synthase
  • hydrogen peroxide
  • dna damage
  • ischemia reperfusion injury
  • diabetic rats
  • high glucose
  • vascular endothelial growth factor
  • heat stress