In Patients with Membranous Lupus Nephritis, Exostosin-Positivity and Exostosin-Negativity Represent Two Different Phenotypes.
Aishwarya RavindranMarta Casal MouraFernando C FervenzaSamih H NasrMariam P AlexanderMary E FidlerLoren P Herrera HernandezPingchuan ZhangJoseph P GrandeLynn D CornellLou Ann GrossVivian NegronGrace E JensonBenjamin J MaddenM Cristine CharlesworthSanjeev SethiPublished in: Journal of the American Society of Nephrology : JASN (2021)
The prevalence of EXT1/EXT2 positivity was 32.6% in our cohort of membranous lupus nephritis. Compared with EXT1/EXT2-negative membranous lupus nephritis, EXT1/EXT2-positive disease appears to represent a subgroup with favorable kidney biopsy findings with respect to chronicity indices. Cases of membranous lupus nephritis that are EXT1/EXT2-negative are more likely to progress to ESKD compared with those that are EXT1/EXT2-positive.
Keyphrases