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Altered Amygdala Volumes and Microstructure in Focal Epilepsy Patients with Tonic-Clonic Seizures, Ictal and Post-convulsive central apnea.

Claudia ZeicuAntoine LegouhyCatherine A ScottJoana F A OliveiraGavin P WinstonJohn S DuncanSjoerd B VosMaria ThomSamden D LhatooHui ZhangRonald M HarperBeate Diehl
Published in: Epilepsia (2023)
Individuals with FBTCpos and PCCA show significantly increased amygdala volumes and disrupted architecture bilaterally, with greater changes on the left side. The structural alterations reflected by NODDI and volume differences may be associated with inappropriate cardiorespiratory patterns mediated by the amygdala, particularly after FBTCS. Determination of amygdala volumetric and architectural changes may assist identification of individuals at risk.
Keyphrases
  • temporal lobe epilepsy
  • functional connectivity
  • resting state
  • prefrontal cortex
  • obstructive sleep apnea
  • body composition
  • stress induced
  • white matter
  • multiple sclerosis
  • solid phase extraction