Profiling of syngeneic mouse HCC tumor models as a framework to understand anti-PD-1 sensitive tumor microenvironments.
Daniel J ZabranskyLudmila DanilovaJames M LeathermanTamara Y Lopez-VidalJessica SanchezSoren CharmsazNicole E GrossSarah ShinXuan YuanAlexei HernandezHongqui YangStephanie XavierDaniel ShuAli SaeedKabeer MunjalZeal KamdarLuciane T KagoharaElizabeth M JaffeeMark YarchoanWon Jin HoPublished in: Hepatology (Baltimore, Md.) (2022)
There is a wide diversity in the immune tumor microenvironments in preclinical models and in human HCC, highlighting the need to use multiple syngeneic HCC models to improve the understanding of how to treat HCC through immune modulation.