Characterization of Aripiprazole Uptake Transporter in the Blood-Brain Barrier Model hCMEC/D3 Cells by Targeted siRNA Screening.

Moeno KadoguchiHiroshi ArakawaRyokichi HondaKazuki HottaYoshiyuki ShirasakaYoshiharu DeguchiIkumi Tamai

Published in: Pharmaceutical research (2022)

values showed that aripiprazole was a potential substrate of OCTN2. The technique described in this study can be applied to identifying novel BBB transporters for CNS drugs.

Keyphrases

blood brain barrier
induced apoptosis
cancer therapy
cell cycle arrest
risk assessment
signaling pathway
oxidative stress
endoplasmic reticulum stress
climate change