The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities.

Xue-Gang HeYing LiBo DengAixin LinGuangzhi ZhangMiao MaYonggang WangYong YangXue-Wen Kang

Published in: Cell proliferation (2022)

The PI3K/AKT signaling pathway has an important role in the recovery of spinal cord function after secondary injury. Inducing the activation of PI3K/AKT signaling pathway in the subacute phase of secondary injury and inhibiting this pathway in the chronic phase may be one of the potential strategies for the treatment of TSCI.

Keyphrases

signaling pathway
pi k akt
spinal cord injury
spinal cord
cell cycle arrest
neuropathic pain
cell death
induced apoptosis
epithelial mesenchymal transition
oxidative stress
cell proliferation
replacement therapy
climate change
combination therapy
drug induced