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Reduced phosphodiesterase-2 activity in the amygdala results in anxiolytic-like effects on behavior in mice.

Ling ChenSuying CuiHaiyang YuGaowen LiNa LiuQiang WuHan-Ting ZhangJames M O'DonnellGang WangYing Xu
Published in: Journal of psychopharmacology (Oxford, England) (2019)
The results suggest that PDE2A plays a crucial role in the regulation of anxiety by the cGMP/cAMP-dependent pVASP-pCREB-BDNF signaling pathway.
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