SEPT9 and SHOX2 DNA methylation status and its utility in the diagnosis of colonic adenomas and colorectal adenocarcinomas.

Alexander SemaanAnne van EllenSebastian MellerDominik BergheimVittorio BranchiPhilipp LingohrDiane GoltzJörg C KalffGlen KristiansenHanno MatthaeiDimitrios PantelisDimo Dietrich

Published in: Clinical epigenetics (2016)

SEPT9/SHOX2 methylation assays may help to distinguish colorectal cancer and adenomas from normal and inflammatory colonic tissue, as well as advanced from non-advanced adenomas. Further studies need to validate these findings before introduction in clinical routine.

Keyphrases

dna methylation
genome wide
ulcerative colitis
gene expression
oxidative stress
high throughput
clinical practice
single cell