Cancer Associated Fibroblast (CAF) Regulation of PDAC Parenchymal (CPC) and CSC Phenotypes Is Modulated by ECM Composition.

Stefania CannoneMaria Raffaella GrecoTiago Miguel Amaral CarvalhoHelene GuizouarnOlivier SorianiDaria Di MolfettaRichard TomasiniKatrine ZeebergStephan Joel Reshkin Rosa Angela Cardone

Published in: Cancers (2022)

We conclude that the CAFs and acellular stromal components interact to modulate the tumor behaviors of the PDAC CPC and CSC cell types and drive metastatic progression by stimulating the phenotypic characteristics of each tumor cell type that contribute to metastasis.

Keyphrases

squamous cell carcinoma
small cell lung cancer
single cell
bone marrow
cell therapy
stem cells
extracellular matrix