Pathophysiological associations of transcallosal dysfunction in ALS.
Mehdi A J van den BosMana HigashiharaNimeshan GeevasingaParvathi MenonMatthew C KiernanSteve VucicPublished in: European journal of neurology (2020)
The present study has established that dysfunction of transcallosal circuits was an important pathophysiological mechanism in ALS, correlating with greater disability and a faster rate of disease progression. Therapies aimed at restoring the function of transcallosal circuits may be considered for therapeutic approaches in ALS.