Toxic epidermal necrolysis after first dose of Pfizer-BioNTech (BNT162b2) vaccination with pharmacogenomic testing.
Nunthana SiripipattanamongkolSirawich RattanasakChanya TaiyaitiengYanapha InthajakNitchamon KuawatcharawongChonlaphat SukasemTherdpong TemparkPublished in: Pediatric dermatology (2022)
Toxic epidermal necrolysis (TEN) is a rare and acute life-threatening condition and one of the severe cutaneous adverse drug reactions. There are limited data on TEN from the COVID-19 vaccine regarding its pathogenesis, treatment, and prognosis, particularly in children. We report a case of COVID-19 vaccine-induced TEN and the patient's human leukocyte antigen pharmacogenomic profile.
Keyphrases
- adverse drug
- drug induced
- coronavirus disease
- sars cov
- electronic health record
- clinical decision support
- endothelial cells
- high glucose
- liver failure
- young adults
- wound healing
- case report
- diabetic rats
- emergency department
- respiratory failure
- respiratory syndrome coronavirus
- big data
- aortic dissection
- early onset
- intensive care unit
- peripheral blood
- deep learning
- acute respiratory distress syndrome
- stress induced