Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes in a cohort of Peruvian tuberculosis patients.
Kelly S LevanoLuis Jaramillo-ValverdeDavid D TarazonaCesar SanchezSilvia CapristanoTania Vásquez-LoarteLely SolariAlberto Mendoza-TiconaAlonso Ricardo Soto-TarazonaChristian RojasRoberto Zegarra ChapoñanHeinner GuioPublished in: Molecular genetics & genomic medicine (2021)
This high prevalence of slow metabolizers for isoniazid in the Peruvian population should be further studied and considered to help individualize drug regimens, especially in countries with a great genetic diversity like Peru. These data will help the Peruvian National Tuberculosis Control Program develop new strategies for therapies.
Keyphrases
- mycobacterium tuberculosis
- genetic diversity
- end stage renal disease
- quality improvement
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- hiv aids
- peritoneal dialysis
- emergency department
- electronic health record
- gene expression
- dna methylation
- artificial intelligence
- hepatitis c virus
- deep learning
- hiv infected
- patient reported