Fixed Dose Single Tablet Formulation with Differential Release of Amlodipine Besylate and Simvastatin and Its Pharmacokinetic Profile: QbD and Risk Assessment Approach.
Ummarah KanwalShahid MukhtarMuzzamil WaheedArifa MehreenNasir AbbasRahat ShamimKhalid HussainFatima RasoolAmjad HussainNadeem Irfan BukhariPublished in: Drug design, development and therapy (2021)
The pharmacokinetic study showed an immediate absorption of AML-B while that of SIM was withheld for 6 h, close to the desired delay time of 8 h.