Quality evaluation of case series describing four-factor prothrombin complex concentrate in oral factor Xa inhibitor-associated bleeding: a systematic review.

Olivia S CostaWilliam L BakerYuani Roman-MorilloKelly McNeil-PoseyBelinda LovelaceC Michael WhiteCraig I Coleman

Published in: BMJ open (2020)

Although many case series describe off-label use of 4F-PCC for oFXa inhibitor-related bleeding, methodological flaws and/or poor reporting necessitates caution in interpretation.

Keyphrases

atrial fibrillation
adverse drug
emergency department