Inhibition of heat shock protein (HSP) 90 reverses signal transducer and activator of transcription (STAT) 3-mediated muscle wasting in cancer cachexia mice.
Mengyuan NiuShiyu SongZhonglan SuLulu WeiLi LiWenyuan PuChen ZhaoYibing DingJinglin WangWangsen CaoQian GaoHongwei WangPublished in: British journal of pharmacology (2021)
The HSP90/STAT3/FOXO1 axis plays a critical role in cachectic muscle wasting, which might be a potential therapeutic target for the treatment of cancer cachexia.
Keyphrases
- adipose tissue
- heat shock protein
- papillary thyroid
- heat shock
- squamous cell
- skeletal muscle
- transcription factor
- cell proliferation
- heat stress
- squamous cell carcinoma
- lymph node metastasis
- signaling pathway
- metabolic syndrome
- risk assessment
- immune response
- human health
- climate change
- combination therapy
- smoking cessation