Integrated genomic and transcriptomic analysis reveals the activation of PI3K signaling pathway in HPV-independent cervical cancers.
Yi WangMisi HeTiancong HeXueyan OuyangXuxia ShenWanling ShiShengling HuangLibing XiangDongling ZouWei JiangHuijuan YangPublished in: British journal of cancer (2024)
This study reveals the prevalence, clinicopathology, and molecular features of HPV-ind CCs and emphasizes the importance of PIK3CA mutations and PI3K pathway activation in tumorigenesis, which suggests the potential significance of PI3Kα inhibitors in HPV-ind CC patients.
Keyphrases
- high grade
- signaling pathway
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- risk factors
- prognostic factors
- cervical cancer screening
- epithelial mesenchymal transition
- copy number
- patient reported outcomes
- risk assessment
- oxidative stress
- human health
- single molecule
- young adults
- climate change
- cell proliferation
- endoplasmic reticulum stress