Two-hour infusion of vasoactive intestinal polypeptide induces delayed headache and extracranial vasodilation in healthy volunteers.
Lanfranco PellesiMohammad Al-Mahdi Al-KaragholiBasit Ali ChaudhryCristina Lopez LopezJosefin SnellmanJens HannibalFaisal Mohammad AminMessoud AshinaPublished in: Cephalalgia : an international journal of headache (2020)
Continuous intravenous infusion of VIP over 2 h induced a long-lasting cranial vasodilation, activation of the cranial parasympathetic system, and delayed mild headaches in healthy volunteers.Trial Registration: The study is registered at ClinicalTrials.gov (NCT03989817).