Fast-Acting Black-Phosphorus-Assisted Depression Therapy with Low Toxicity.

Liguo JinPing HuYinyin WangLuojia WuKang QinHaoxin ChengShuhua WangBingxing PanHongbo XinWenhua ZhangXiaolei Wang

Published in: Advanced materials (Deerfield Beach, Fla.) (2019)

A black phosphorus (BP)-nanosheet-based drug-delivery system containing a therapeutic drug (Fluoxetine, Flu) is synthesized. According to subsequent behavioral, biochemical, and electrophysiological analysis, BP-Flu, after irradiated with near-infrared light (808 nm), can significantly reduce the therapy time of depression. Meanwhile, the inherent biotoxicity of Flu is also alleviated.

Keyphrases

depressive symptoms
sleep quality
photodynamic therapy
emergency department
stem cells
mesenchymal stem cells
heavy metals
drug induced
electronic health record
anaerobic digestion