Identification of Somatically Acquired BRCA1/2 Mutations by cfDNA Analysis in Patients with Metastatic Breast Cancer.

Neelima VidulaTaronish DubashMichael S LawrenceAntoine SimoneauAndrzej NiemierkoErica BlouchBecky NagyWhijae RohBrian ChirnBrittany A ReevesGiuliana MalvarosaJochen K LennerzSteven J IsakoffDejan JuricDouglas S MicalizziSeth WanderLaura SpringBeverly MoyKristen ShannonJerry YoungerRichard B LanmanMehmet TonerA John IafrateGad A GetzLee ZouLeif W EllisenShyamala MaheswaranDaniel A HaberAditya Bardia

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Somatic BRCA1/2 mutations are readily detectable in MBC by cfDNA analysis, and may be present as both known germline pathogenic and novel variants.

Keyphrases

metastatic breast cancer
copy number
dna repair
oxidative stress
dna damage
genome wide