Efficacy and Safety of Systemic and Locoregional Cisplatin Chronotherapy in Rats with Ovarian Carcinoma.

Galina Kireeva Ekaterina A Gubareva Mikhail A MaidinVladislav OsetnikStepan KruglovAndrey V PanchenkoAnastasia DorofeevaMargarita TyndykElena FedorosVladimir Anisimov

Published in: OncoTargets and therapy (2021)

In a rat model, ovarian tumor growth disrupted daily variations in intestinal epithelium proliferation and caused genotoxic stress in tumor-free tissues. HIPEC with cisplatin at ZT0 had a better efficacy/toxicity profile than HIPEC with cisplatin at ZT12 and IV administration at both time points.

Keyphrases

signaling pathway
gene expression
physical activity
oxidative stress
resting state