Nicorandil attenuates high glucose-induced insulin resistance by suppressing oxidative stress-mediated ER stress PERK signaling pathway.

Zhongwei LiuHaitao ZhuChunhui HeTing HeShuo PanNa ZhaoLing ZhuGongchang GuanPeng LiuYong ZhangJunkui Wang

Published in: BMJ open diabetes research & care (2021)

By reducing cytoplasmic calcium, nicorandil alleviated high glucose-induced insulin resistance by inhibiting oxidative stress-mediated ER stress PERK pathway.

Keyphrases

high glucose
endothelial cells
insulin resistance
oxidative stress
signaling pathway
endoplasmic reticulum stress
induced apoptosis
adipose tissue
diabetic rats
type diabetes
high fat diet
metabolic syndrome
dna damage
stress induced