pH/glutathione-responsive release of SO2 induced superoxide radical accumulation for gas therapy of cancer.
Rui GuLei WangXiaoyu HuangJiayao ZhangChangjin OuWeili SiJianguang YuWenjun WangXiaochen DongPublished in: Chemical communications (Cambridge, England) (2021)
A pH/GSH-responsive SO2 generation nanoplatform (BODS NPs) is established to achieve lysosomal escape and GSH depletion in tumor cells. O2˙- as the main ROS during SO2-mediated gas therapy can be accumulated through Cu/Zn-SOD enzymatic activity suppression and mitochondrial biogenesis, further exacerbating the oxidative stress and resulting in cell apoptosis.
Keyphrases
- oxidative stress
- cancer therapy
- diabetic rats
- dna damage
- hydrogen peroxide
- room temperature
- cell proliferation
- fluorescent probe
- papillary thyroid
- cell death
- photodynamic therapy
- heavy metals
- drug delivery
- stem cells
- young adults
- lymph node metastasis
- cell therapy
- bone marrow
- ionic liquid
- induced apoptosis
- smoking cessation