Targeted Interleukin-9 delivery in pulmonary hypertension: Comparison of immunocytokine formats and effector cell study.

Judith HeissKatja GrünLaura TempelMattia MatasciAndrea SchrepperMichael SchwarzerReinhard BauerMartin FörsterAlexander BerndtChristian JungP Christian SchulzeDario NeriMarcus Franz

Published in: European journal of clinical investigation (2022)

Beneficial treatment effects of targeted IL9 delivery in a preclinical model of PH could be convincingly validated. IL9-mediated recruitment of Tregs into lung tissue might play a crucial role in the induction of anti-inflammatory and anti-proliferative mechanisms potentially contributing to a novel disease-modifying concept.

Keyphrases

pulmonary hypertension
anti inflammatory
cancer therapy
cell therapy
single cell
dendritic cells
pulmonary artery
pulmonary arterial hypertension
stem cells
regulatory t cells
combination therapy
mesenchymal stem cells
drug delivery
replacement therapy