Exposure-Toxicity Association of Cyclophosphamide and Its Metabolites in Infants and Young Children with Primary Brain Tumors: Implications for Dosing.
Olivia CampagneBo ZhongSreenath NairTong LinJie HuangArzu Onar-ThomasGiles W RobinsonAmar GajjarClinton F StewartPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
A 4OH-CTX exposure-toxicity association was established, and a decreased cyclophosphamide dosage for young infants was suggested to reduce toxicity in this population. Bayesian modeling to predict 4OH-CTX exposure may reduce clinical processing-related costs and provide insights into further exposure-response associations.
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