Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
Tialfi Bergamin De CastroGabriela Helena Rodrigues-FlemingJuliana Garcia De Oliveira-CucoloJéssika Nunes Gomes Da SilvaFabia Pigatti SilvaLuiz Sergio RaposoJosé Victor ManigliaÉrika Cristina PavarinoLidia Maria Rebolho Batista ArantesAna Lívia Silva Galbiatti-DiasEny Maria Goloni-BertolloPublished in: Asian Pacific journal of cancer prevention : APJCP (2020)
DNMT3B -283T/C is associated with higher risk, whereas DHFR 19-pb ins/del and TYMS 28 3R/3R protect against head and neck cancer. We also highlighted the association of TYMS 3R/3R genotype carriers with relapse-free cancer protection and survival time.