Login / Signup

Chromogranin A-positive hormone-negative endocrine cells in pancreas in human pregnancy.

Abu Saleh Md MoinKylie ZengRobert A RizzaSangeeta DhawanAlexandra E Butler
Published in: Endocrinology, diabetes & metabolism (2021)
Our findings of no increase in CPHN cell frequency in pancreas of pregnant women suggest that this potential β-cell regenerative mechanism is not that by which the increased β-cell mass of pregnancy is achieved. However, an increase in the percentage of clustered β-cells was found in pregnancy, with decreased frequency of other endocrine cells in clusters, suggesting a compensatory shift from other pancreatic endocrine cell types to β-cells as a mechanism to meet the increased insulin demands of pregnancy.
Keyphrases