Lithium-oxygen batteries (LOBs) with a theoretical energy density of up to 3500 Wh kg -1 hold a promise for the next-generation high-energy-density batteries. However, the slow oxygen reduction/evolution kinetics at the cathode limits the performance of Li-air batteries. The rational design of efficient catalysts is essential for the improvement of oxygen electrode reaction kinetics. Herein, we report a facile strategy to co-dope N and P atoms simultaneously into Ti 3 C 2 T x (NP-Ti 3 C 2 T x ) MXene via an electrostatic self-assembly approach. The co-doped NP-Ti 3 C 2 T x layers expose abundant active sites, providing more space for accommodating the formed Li 2 O 2 . Moreover, the N and P co-doping facilitates efficient electron transport in Ti 3 C 2 T x MXene. The LOB with NP-Ti 3 C 2 T X catalyst delivers a high discharge capacity of 24,940 mAh/g at 1000 mA g -1 . At a cut-off capacity of 1000 mAh/g, this battery runs continuously for 159, 276, 185, and 229 cycles at current densities of 1000, 2000, 3000, and 5000 mA g -1 , respectively. Theoretical calculations unveil that N and P co-doping enables lower η ORR and η OER of only 0.26 V and 0.13 V on Ti 3 C 2 T x MXene, respectively. This work offers a feasible approach for constructing efficient MXene electrocatalysts for Li-air batteries.