LncCDCA3L inhibits cell proliferation via a novel RNA structure-based crosstalk with CDCA3 in hepatocellular carcinoma.

Yongfeng WangYongzhen LiuTing ZhangGuiwen GuanTianhao MaoHui LiuJing ZhangFeng-Min Lu Xiangmei Chen

Published in: Liver international : official journal of the International Association for the Study of the Liver (2022)

Our study collectively unveiled the molecular mechanisms of how lncCDCA3L repressed the tumourigenic properties of HCC cells and exhibited a tumour suppressor character in HCC in a CDCA3-dependent manner. The findings here support lncCDCA3L can be used as a candidate prognostic biomarker for HCC patients.

Keyphrases

cell proliferation
end stage renal disease
induced apoptosis
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
oxidative stress
signaling pathway
endoplasmic reticulum stress
cell death
patient reported