Ara h 2-specific IgE epitope-like peptides inhibit the binding of IgE to Ara h 2 and suppress lgE-dependent effector cell activation.
Peter KorosecAna KorenJerneja DebeljakAbida ZahirovićMaja Skerbinjek-KavalarVojko BerceLuka DejanovićJernej LuzarBorut ŠtrukeljMojca LunderPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2023)
These studies show that the indicated peptides reduce the allergenic activity of Ara h 2 and suppress lgE-dependent basophil and mast cell activation. These observations may suggest a novel therapeutic strategy for food allergy based on epitope-paratop blocking.