White matter degeneration profile in the cognitive cortico-subcortical tracts in Parkinson's disease.
Alexandru HanganuJean-Christophe HoudeVladimir S FonovClotilde DegrootBeatriz Mejia-ConstainAnne-Louise LafontaineValérie SolandSylvain ChouinardLouis D CollinsMaxime DescoteauxOury MonchiPublished in: Movement disorders : official journal of the Movement Disorder Society (2018)
Both PD groups showed similar patterns of white matter neurodegeneration in the motor bundles, whereas cognitive bundles showed a distinct pattern: Parkinson's patients with normal cognition had white matter diffusivity metrics similar to healthy controls, whereas in patients with cognitive impairment white matter showed a neurodegeneration pattern. © 2018 International Parkinson and Movement Disorder Society.