Regional Differences in Blood-Brain Barrier Permeability in Cognitively Normal Elderly Subjects: A Dynamic Contrast-Enhanced MRI-Based Study.

Il Heon Ha Changmok Lim Yeahoon Kim Yeonsil Moon Seol-Heui Han Won Jin Moon

Published in: Korean journal of radiology (2021)

Our study demonstrated regional differences in BBB permeability (Ktrans) in cognitively normal elderly adults using a clinically acceptable 10-minutes DCE imaging protocol. The regional differences suggest that the integrity of the BBB varies across the brains of cognitively normal elderly adults. We recommend considering regional differences in Ktrans values when evaluating BBB permeability in patients with neurodegenerative diseases.

Keyphrases

blood brain barrier
middle aged
cognitive decline
cerebral ischemia
mild cognitive impairment
endothelial cells
community dwelling
magnetic resonance imaging
contrast enhanced
high resolution
computed tomography
magnetic resonance
brain injury
subarachnoid hemorrhage
fluorescence imaging