Lipocalin 2 Enhances Migration and Resistance against Cisplatin in Endometrial Carcinoma Cells.
Tsutomu MiyamotoHiroyasu KashimaYasushi YamadaHisanori KobaraRyoichi AsakaHirofumi AndoShotaro HiguchiKoichi IdaDavid Hamisi MvuntaTanri ShiozawaPublished in: PloS one (2016)
These results indicated that LCN2 was involved in the migration and survival of endometrial carcinoma cells under various stresses in an iron-dependent manner. The survival function of LCN2 may be exerted through the PI3K pathway and suppression of the p53-p21 pathway. These functions of LCN2 may increase the malignant potential of endometrial carcinoma cells.