OLFM4 Regulates Lung Epithelial Cell Function in Sepsis-Associated ARDS/ALI via LDHA-Mediated NF-κB Signaling.
Fang-Chen GongRanran LiXiangtao ZhengWeiwei ChenYanjun ZhengZhi-Tao YangYing ChenHongping QuEnqiang MaoErzhen ChenPublished in: Journal of inflammation research (2021)
OLFM4 may regulate the pro-inflammatory response of lung epithelial cells in sepsis-related ARDS by modulating metabolic disorders; this result could provide new insights into the treatment of sepsis-induced ARDS.
Keyphrases
- acute respiratory distress syndrome
- septic shock
- inflammatory response
- intensive care unit
- acute kidney injury
- mechanical ventilation
- extracorporeal membrane oxygenation
- signaling pathway
- lps induced
- oxidative stress
- lipopolysaccharide induced
- drug induced
- high glucose
- diabetic rats
- anti inflammatory
- combination therapy
- cell proliferation