Glial activation in pain and emotional processing regions in the nitroglycerin mouse model of chronic migraine.

Haley C CropperCatherine M ConwayWhitney WycheAmynah Amir Ali Pradhan

Published in: Headache (2024)

Immunohistochemical analysis suggests that, at the time point tested, immunoreactivity of GFAP+ astrocytes, but not Iba1+ microglia, changes in response to chronic migraine-associated pain. Additionally, there do not appear to be significant differences between males and females in GFAP+ or Iba1+ cells across the four brain regions analyzed.

Keyphrases

neuropathic pain
chronic pain
mouse model
pain management
induced apoptosis
spinal cord
spinal cord injury
cell cycle arrest
inflammatory response
oxidative stress
cell death
multiple sclerosis
resting state
drug induced
postoperative pain
blood brain barrier
pi k akt