Involvement of inflammation in the medial temporal region in the development of agitation in Alzheimer's disease: an in vivo positron emission tomography study.
Fumihiko YasunoYasuyuki KimuraAya OgataHiroshi IkenumaJunichiro AbeHiroyuki MinamiTakashi NihashiKastunori YokoiSaori HattoriNobuyoshi ShimodaAtsushi WatanabeKensaku KasugaTakeshi IkeuchiAkinori TakedaTakashi SakuraiKengo ItoTakashi KatoPublished in: Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society (2022)
Neuroinflammation in the medial temporal region and its neighbouring area was shown to be associated with the development of agitation symptoms in AD patients. Our findings extend those of previous studies showing an association between some NPS and inflammation, suggesting that immunologically based interventions for agitation can serve as an alternative treatment for dementia.
Keyphrases
- positron emission tomography
- computed tomography
- end stage renal disease
- oxidative stress
- chronic kidney disease
- newly diagnosed
- ejection fraction
- cognitive impairment
- mild cognitive impairment
- peritoneal dialysis
- traumatic brain injury
- prognostic factors
- physical activity
- patient reported outcomes
- patient reported