"Inhibitory immune checkpoints predict 7-day, in-hospital and 1-year mortality of internal medicine patients admitted with bacterial sepsis".

Filippo MearelliAlessio NunnariAnnalisa RombiniFederica ChittiFrancesca SpagnolChiara CasarsaGiulia BolzanIlaria MartiniAnna MarinelliStefania RizzoCristiana TesoAlessandra MacorNicola FiottiGiulia BarbatiCarlo TasciniVenera CostantinoStefano Di BellaFilippo Giorgio Di GirolamoTiziana BoveDaniele OrsoGiorgio BerlotMichael KlompasGianni Biolo

Published in: The Journal of infectious diseases (2024)

Two inhibitory immune checkpoint biomarkers (IRAK-M and Galectin-1) helped identify 3 distinct sepsis phenotypes with distinct prognoses. These biomarkers shed light on the interplay between immune dysfunction and prognosis in patients with bacterial sepsis and may prove to be useful prognostic markers, therapeutic targets, and biochemical markers for targeted enrollment in targeted therapeutic trials.

Keyphrases

septic shock
acute kidney injury
intensive care unit
cancer therapy
oxidative stress
cardiovascular events
risk factors
type diabetes
adverse drug
coronary artery disease
drug induced