A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy.

Gist H FarrMelanie MorrisArianna GomezThao PhamElisabeth KilroyElizabeth U ParkerShery SaidClarissa HenryLisa Maves

Published in: Skeletal muscle (2020)

Our results provide novel, effective methods for performing a combination of small-molecule screen in zebrafish. Our results also add to the growing evidence that epigenetic small molecules may be promising candidates for treating DMD.

Keyphrases

small molecule
duchenne muscular dystrophy
dna methylation
protein protein
high throughput
gene expression
muscular dystrophy
genome wide
smoking cessation