Are B cells altered in the decidua of women with preterm or term labor?

Yaozhu LengRoberto RomeroYi XuJose GalazRebecca SlutskyMarcia Arenas-HernandezValeria Garcia-FloresKenichiro MotomuraSonia S HassanAndrea ReboldiNardhy Gomez-Lopez

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)

Total B cells are not increased with the presence of preterm or term labor; yet, specific subsets (B1 and plasmablasts) undergo alterations in women with chronic chorioamnionitis. Therefore, B cells are solely implicated in the pathological process of preterm labor in a subset of women with chronic inflammation of the placenta. These findings provide insight into the immunology of the maternal-fetal interface in preterm and term labor.

Keyphrases

gestational age
birth weight
low birth weight
preterm infants
preterm birth
oxidative stress
body mass index
drug induced
weight gain