Astragalus Polysaccharide Enhances Voriconazole Metabolism under Inflammatory Conditions through the Gut Microbiota.

Xiaokang WangXianjing HuChunxiao YeJingqian ZhaoShing Cheng TanLiangbin ZhouChenyu ZhaoKit Hang WuXixiao YangJinbin Wei Maoxun Yang

Published in: Journal of clinical and translational hepatology (2024)

The study offers valuable insights into the mechanism by which APS alleviates VRC-induced liver damage, highlighting its immunomodulatory influence on hepatic tissues and its indirect regulatory control of VRC-metabolizing enzymes within hepatocytes.

Keyphrases

oxidative stress
diabetic rats
high glucose
gene expression
drug induced
liver injury
transcription factor
mouse model
endothelial cells