Circulating tumor DNA as a dynamic biomarker of response to palbociclib and fulvestrant in metastatic breast cancer patients.
Lauren DarriguesJean-Yves PiergaAlice Bernard-TessierIvan BiècheAmanda Bartolini SilveiraMarc MichelDelphine LoiratPaul CottuLuc CabelCoraline DubotRomain GeissFrancesco RicciAnne Vincent-SalomonCharlotte ProudhonFrancois-Clement BidardPublished in: Breast cancer research : BCR (2021)
Our study demonstrates that the efficiency of palbociclib and fulvestrant can be monitored by serial analyses of ctDNA before radiological evaluation and that early ctDNA variation is a prognostic factor of PFS.