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Emerging Trends in Micro- and Nanoscale Technologies in Medicine: From Basic Discoveries to Translation.

Mario Moisés ÁlvarezJoanna AizenbergMostafa AnalouiAnne Milasincic AndrewsGili BiskerEdward S BoydenRoger Dale KammJeffrey M KarpDavid J MooneyRahmi OkluDan PeerMichelle StolzoffMichael S StranoGrissel Trujillo-de SantiagoThomas J WebsterPaul S WeissAli Khademhosseini
Published in: ACS nano (2017)
We discuss the state of the art and innovative micro- and nanoscale technologies that are finding niches and opening up new opportunities in medicine, particularly in diagnostic and therapeutic applications. We take the design of point-of-care applications and the capture of circulating tumor cells as illustrative examples of the integration of micro- and nanotechnologies into solutions of diagnostic challenges. We describe several novel nanotechnologies that enable imaging cellular structures and molecular events. In therapeutics, we describe the utilization of micro- and nanotechnologies in applications including drug delivery, tissue engineering, and pharmaceutical development/testing. In addition, we discuss relevant challenges that micro- and nanotechnologies face in achieving cost-effective and widespread clinical implementation as well as forecasted applications of micro- and nanotechnologies in medicine.
Keyphrases
  • circulating tumor cells
  • drug delivery
  • tissue engineering
  • high resolution
  • healthcare
  • primary care
  • atomic force microscopy
  • quality improvement
  • cancer therapy
  • single molecule
  • high speed
  • cell free