Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3.
Angelika SchmidtFrancesco MarabitaNarsis A KianiCatharina C GrossHenrik J JohanssonSzabolcs ÉliásSini RautioMatilda ErikssonSunjay Jude FernandesGilad SilberbergUbaid UllahUrvashi BhatiaHarri LähdesmäkiJanne LehtiöDavid Gomez-CabreroHeinz WiendlRiitta LahesmaaJesper TegnérPublished in: BMC biology (2018)
The data generated by this novel approach facilitates understanding of the molecular mechanisms underlying iTreg generation as well as of the concomitant changes in the transcriptome and proteome. Our results provide a reference map exploitable for future discovery of markers and drug candidates governing control of Tregs, which has important implications for the treatment of cancer, autoimmune, and inflammatory diseases.
Keyphrases
- single cell
- rna seq
- endothelial cells
- transcription factor
- genome wide
- gene expression
- papillary thyroid
- small molecule
- regulatory t cells
- high throughput
- electronic health record
- multiple sclerosis
- oxidative stress
- drug induced
- current status
- squamous cell
- induced pluripotent stem cells
- machine learning
- emergency department
- adverse drug
- young adults
- replacement therapy